N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide

Base Information

Chemical Name:N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide
CAS No.:279246-07-0
Molecular Formula:C₃₃H₂₅F₃N₂O₇S
Molecular Weight:650.632
Hs Code.:

Synonyms:N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide

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Chemical Property of N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide

Chemical Property:

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Technology Process of N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide

There total 4 articles about N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 279246-06-9
2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]sulfonyl](phenylmethoxycarbonyl)amino]methyl]-1-naphthalenecarboxylic Acid

: 279246-07-0
N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: C₃₃H₂₃ClF₃NO₆S

: 279246-07-0
N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm020160g

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 279246-07-0
N-hydroxy-2-[[[[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-sulfonyl](phenylmethoxycarbonyl)amino]methyl]1-naphthalenecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 77 percent / dimethylformamide / 2 h

2.1: 100 percent / TFA / CH₂Cl₂ / 1 h / 0 °C

3.1: (COCl)2; DMF / CH₂Cl₂ / 0 - 20 °C

4.1: 0.459 g / aq. NH₂OH*HCl; Et₃N / tetrahydrofuran / 3 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020160g