(E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

Base Information

Chemical Name:(E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate
CAS No.:1431465-35-8
Molecular Formula:C₂₅H₁₉FO₄
Molecular Weight:402.422
Hs Code.:

Synonyms:(E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

Suppliers and Price of (E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

Chemical Property:

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Technology Process of (E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

There total 3 articles about (E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1431465-63-2
1-(4-(3-(2-bromo-4-fluorophenoxy)prop-1-ynyl)phenyl)ethanone

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1431465-35-8
(E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In 1,4-dioxane; at 100 ℃; for 2h;
DOI:10.1021/jo400503f

Reference yield:

: 457628-49-8
2-bromo-4-fluoro-1-(prop-2-yn-1-yloxy)benzene

: 1431465-35-8
(E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / 1,4-dioxane / 2 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jo400503f

Reference yield:

: 13329-40-3
4-Iodoacetophenone

: 1431465-35-8
(E)-methyl 4-((4-acetylphenyl)(5-fluorobenzofuran-3(3H)-ylidene)methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / 1,4-dioxane / 2 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jo400503f