ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate

Base Information

Chemical Name:ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate
CAS No.:121590-52-1
Molecular Formula:C₂₄H₂₅Cl₂NO₇
Molecular Weight:510.371
Hs Code.:

Synonyms:ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate

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Chemical Property of ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate

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Technology Process of ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate

There total 6 articles about ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-96-4
ethyl bromide

: 101411-64-7
4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

: 121590-52-1
ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; In dimethyl sulfoxide; Yield given;
DOI:10.1021/jm00130a026

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 121590-52-1
ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH / 1) THF, oil, ice cooling, 2) THF, 16 h

2: 1) piperidine / 1) 2-propanol, 24 h, 2) 4 d

3: 1) nBuLi / 1) hexane, THF, -65 deg C, 2.5 h, 2) 2 h, to 0 deg C

4: 1) Triton B / dimethylsulfoxide

With piperidine; n-butyllithium; N-benzyl-trimethylammonium hydroxide; sodium hydride; In dimethyl sulfoxide;
DOI:10.1021/jm00130a026

Reference yield:

: 101411-65-8
1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

: 121590-52-1
ethyl 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) nBuLi / 1) hexane, THF, -65 deg C, 2.5 h, 2) 2 h, to 0 deg C

2: 1) Triton B / dimethylsulfoxide

With n-butyllithium; N-benzyl-trimethylammonium hydroxide; In dimethyl sulfoxide;
DOI:10.1021/jm00130a026