ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate
CAS No.:1439356-98-5
Molecular Formula:C₁₉H₁₃F₃N₂O₅
Molecular Weight:406.318
Hs Code.:

Synonyms:ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate

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Chemical Property of ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate

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Technology Process of ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate

There total 5 articles about ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 64594-45-2
N-methyl-4-nitrobenzimidoyl chloride

: 1439356-98-5
ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate; N-methyl-4-nitrobenzimidoyl chloride; With potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

In N,N-dimethyl-formamide; at 110 ℃; for 1h;
DOI:10.1039/c3cc41690a

Reference yield:

: 2585-23-1
N-methyl-4-nitrobenzamide

: 1439356-98-5
ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 20 °C

2.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 1 h / 110 °C

With thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1039/c3cc41690a

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 1439356-98-5
ethyl 6,7,8-trifluoro-1-methyl-4-oxo-2-(4-nitrophenyl)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 10 - 50 °C / Inert atmosphere

2.2: 0 - 70 °C / Inert atmosphere

2.3: pH 5 - 6

3.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 1 h / 110 °C

With thionyl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; magnesium chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3cc41690a