1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

Base Information

Chemical Name:1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole
CAS No.:1345962-15-3
Molecular Formula:C₂₀H₂₀ClFN₂O₃
Molecular Weight:390.842
Hs Code.:

Synonyms:1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

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Chemical Property of 1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

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Technology Process of 1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

There total 3 articles about 1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257227-17-0
3-chloro-4,5-dimethoxyphenyl(tosyl)methyl isocyanide

: 452-00-6
4-ethoxy-3-fluoro-benzaldehyde

: 74-89-5
methylamine

: 1345962-15-3
1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

Guidance literature:: 4-ethoxy-3-fluoro-benzaldehyde; methylamine; With acetic acid; In ethanol; for 2h; Reflux;

3-chloro-4,5-dimethoxyphenyl(tosyl)methyl isocyanide; With potassium carbonate; In ethanol; for 5h; Reflux;

Reference yield:

: 18268-68-3
5-chloroveratraldehyde

: 1345962-15-3
1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: camphor-10-sulfonic acid / 16 h / 65 °C

2.1: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / -10 - -5 °C

3.1: acetic acid / ethanol / 2 h / Reflux

3.2: 5 h / Reflux

With camphor-10-sulfonic acid; acetic acid; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol;

Reference yield:

: 1245716-01-1
N-[(toluene-4-sulfonyl)-(3-chloro-4,5-dimethoxyphenyl)methyl]formamide

: 1345962-15-3
1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / -10 - -5 °C

2.1: acetic acid / ethanol / 2 h / Reflux

2.2: 5 h / Reflux

With acetic acid; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol;