(R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester
CAS No.:907991-18-8
Molecular Formula:C₂₆H₂₇ClN₂O₃S
Molecular Weight:483.031
Hs Code.:

Synonyms:(R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

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Chemical Property of (R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

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Technology Process of (R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

There total 7 articles about (R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 907991-16-6
(R)-4-(5-Chloro-2-iodo-phenyl)-2-methyl-piperazine-1-carboxylic acid benzyl ester

: 696-63-9
4-Methoxybenzenethiol

: (R)-4-(3-Chloro-phenyl)-2-methyl-piperazine-1-carboxylic acid benzyl ester

: 907991-18-8
(R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: With potassium hydroxide; copper(l) iodide; sarcosine; In 1,4-dioxane; Heating;
DOI:10.1016/j.tetlet.2006.05.117

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 907991-18-8
(R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / K₂CO₃ / ethanol; H₂O / 1 h / Heating

2: 100 percent / NaHCO₃ / CHCl₃ / 0 °C

3: 77 percent / Fe / 60 °C

4: 69 percent / isoamylnitrite; I₂; CsI / CuI / 1,2-dimethoxy-ethane / 1.5 h / 60 °C

5: 63 percent / N-methylglycine; KOH; CuI / dioxane / Heating

With potassium hydroxide; copper(l) iodide; isocyanate de chlorosulfonyle; sarcosine; iodine; iron; sodium hydrogencarbonate; potassium carbonate; isopentyl nitrite; copper(l) iodide; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; chloroform; water;
DOI:10.1016/j.tetlet.2006.05.117

Reference yield:

: 907991-14-4
(R)-4-(5-Chloro-2-nitro-phenyl)-2-methyl-piperazine-1-carboxylic acid benzyl ester

: 907991-18-8
(R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / Fe / 60 °C

2: 69 percent / isoamylnitrite; I₂; CsI / CuI / 1,2-dimethoxy-ethane / 1.5 h / 60 °C

3: 63 percent / N-methylglycine; KOH; CuI / dioxane / Heating

With potassium hydroxide; copper(l) iodide; isocyanate de chlorosulfonyle; sarcosine; iodine; iron; isopentyl nitrite; copper(l) iodide; In 1,4-dioxane; 1,2-dimethoxyethane;
DOI:10.1016/j.tetlet.2006.05.117