(R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine

Base Information

Chemical Name:(R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine
CAS No.:907991-19-9
Molecular Formula:C₁₈H₂₁ClN₂OS
Molecular Weight:348.897
Hs Code.:

Synonyms:(R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine

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Chemical Property of (R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine

Chemical Property:

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Technology Process of (R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine

There total 10 articles about (R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 907991-18-8
(R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester

: 907991-19-9
(R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 4.5h; Heating;
DOI:10.1016/j.tetlet.2006.05.117

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 907991-19-9
(R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / K₂CO₃ / ethanol; H₂O / 1 h / Heating

2: 100 percent / NaHCO₃ / CHCl₃ / 0 °C

3: 77 percent / Fe / 60 °C

4: 69 percent / isoamylnitrite; I₂; CsI / CuI / 1,2-dimethoxy-ethane / 1.5 h / 60 °C

5: 63 percent / N-methylglycine; KOH; CuI / dioxane / Heating

6: 88 percent / aq. HCl / dioxane / 4.5 h / Heating

With hydrogenchloride; potassium hydroxide; copper(l) iodide; isocyanate de chlorosulfonyle; sarcosine; iodine; iron; sodium hydrogencarbonate; potassium carbonate; isopentyl nitrite; copper(l) iodide; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; chloroform; water;
DOI:10.1016/j.tetlet.2006.05.117

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 907991-19-9
(R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / Et₃N / dimethylformamide / 3 h / 80 °C

2: 100 percent / NaHCO₃ / CHCl₃ / 0 °C

3: 77 percent / Fe / 60 °C

4: 69 percent / isoamylnitrite; I₂; CsI / CuI / 1,2-dimethoxy-ethane / 1.5 h / 60 °C

5: 63 percent / N-methylglycine; KOH; CuI / dioxane / Heating

6: 88 percent / aq. HCl / dioxane / 4.5 h / Heating

With hydrogenchloride; potassium hydroxide; copper(l) iodide; isocyanate de chlorosulfonyle; sarcosine; iodine; iron; sodium hydrogencarbonate; triethylamine; isopentyl nitrite; copper(l) iodide; In 1,4-dioxane; 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.05.117