N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Base Information

Chemical Name:N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine
CAS No.:1449668-95-4
Molecular Formula:C₂₄H₂₆N₄O₂
Molecular Weight:402.496
Hs Code.:

Synonyms:N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

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Chemical Property of N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

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Technology Process of N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

There total 10 articles about N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449668-95-4
N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: iron; acetic acid / 1 h / 50 - 80 °C

3.1: 4 h / 100 °C

4.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0 °C

5.2: 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; iron; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 4.1: |Buchwald-Hartwig Coupling;

Reference yield:

: 1449668-94-3
N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridin-6-amine

: 74-88-4
methyl iodide

: 1449668-95-4
N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridin-6-amine; With sodium hexamethyldisilazane; In N,N-dimethyl-formamide; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 929095-68-1
2-bromo-4-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrobenzene

: 1449668-95-4
N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane / 24 h / Reflux

2.1: ammonium chloride; iron / tetrahydrofuran; ethanol; water / 1 h / 90 °C

3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0 °C

4.2: 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; iron; ammonium chloride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 3.1: |Buchwald-Hartwig Coupling;