2-Hydroxy-2,4-dimethyl-3-pentanone

Base Information

• Chemical Name: 2-Hydroxy-2,4-dimethyl-3-pentanone
• CAS No.: 3212-67-7
• Molecular Formula: C7H14 O2
• Molecular Weight: 130.187
• Hs Code.: 2914400090
• Mol file: 3212-67-7.mol

Synonyms:2,4-Dimethyl-2-hydroxy-3-pentanone;2-Hydroxy-2,4-dimethyl-3-pentanone

Chemical Property of 2-Hydroxy-2,4-dimethyl-3-pentanone

Chemical Property:

• PSA: 37.30000
• LogP: 0.98240

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxy-2,4-dimethyl-3-pentanone

There total 1 articles about 2-Hydroxy-2,4-dimethyl-3-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethyl-2-pentene (625-65-0) → 2-hydroxy-3-oxo-2,4-dimethyl-pentane (3212-67-7) + acetic acid (64-19-7,77671-22-8) + acetone (67-64-1) + isobutyric Acid (79-31-2)

Guidance literature:

Reference yield:

2-hydroxy-3-oxo-2,4-dimethyl-pentane (3212-67-7) → 2,4-Dimethyl-3-pentanone (18641-70-8)

Guidance literature:

Multi-step reaction with 5 steps

1: Br₂ / 1 h / 5 - 10 °C

2: DBU / dimethylformamide / 2 h / Ambient temperature

3: 70 percent / Et₃N, DMAP / CH₂Cl₂ / 4 h / 0 °C

4: 10 percent / diethyl ether; various solvent(s) / 0.5 h / -78 °C

5: 82 percent / diethyl ether; various solvent(s) / 0.5 h / -78 °C

With dmap; bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00024a014

Reference yield:

diethyl ether (60-29-7,927820-24-4) + ethanol (64-17-5) + 2-hydroxy-3-oxo-2,4-dimethyl-pentane (3212-67-7) → 2,4-dimethyl-pentane-2,3-diol (66225-53-4)

Guidance literature:

upstream raw materials:

2,4-dimethyl-2-pentene

Downstream raw materials:

2,4-dimethyl-3-phenyl-pentane-2,3-diol

2,4-dimethyl-pentane-2,3-diol

2,4-Dimethyl-3-pentanone