2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole

Base Information

Chemical Name:2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole
CAS No.:251369-19-4
Molecular Formula:C₂₉H₃₈ClN₃O₃
Molecular Weight:512.092
Hs Code.:

2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1<i>H</i>-benzoimidazole

Synonyms:2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole

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Chemical Property of 2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole

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Technology Process of 2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole

There total 8 articles about 2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 16686-11-6
2-(3-chloropropyl)-1,3-dioxolane

: 193626-88-9
1-(3-(4-piperidyl)propyl)-2-(4-chlorophenoxymethyl)-4-methylbenzimidazole

: 251369-19-4
2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1016/S0040-4020(99)00683-3

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 251369-19-4
2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / hydrogen / Rh/C / ethanol / 24 h / 60 °C / 3102.89 Torr

2: 57 percent / potassium carbonate / tetrahydrofuran; H₂O / 5 - 20 °C

3: 90 percent / triphenylphosphine; bromine; pyridine / CH₂Cl₂

4: 74 percent / sodium hydride / dimethylformamide; various solvent(s) / 6 h / 60 °C

5: 89 percent / trifluoroacetic acid / 0.83 h / 20 °C

6: 62 percent / sodium bicarbonate / dimethylformamide / 90 °C

With pyridine; hydrogen; bromine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; Rh on carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Catalytic hydrogenation / 2: Acylation / 3: Bromination / 4: Alkylation / 5: Hydrolysis / 6: Alkylation;
DOI:10.1016/S0040-4020(99)00683-3

Reference yield:

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 251369-19-4
2-(4-chloro-phenoxymethyl)-1-{3-[1-(3-[1,3]dioxolan-2-yl-propyl)-piperidin-4-yl]-propyl}-4-methyl-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / potassium carbonate / tetrahydrofuran; H₂O / 5 - 20 °C

2: 90 percent / triphenylphosphine; bromine; pyridine / CH₂Cl₂

3: 74 percent / sodium hydride / dimethylformamide; various solvent(s) / 6 h / 60 °C

4: 89 percent / trifluoroacetic acid / 0.83 h / 20 °C

5: 62 percent / sodium bicarbonate / dimethylformamide / 90 °C

With pyridine; bromine; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Acylation / 2: Bromination / 3: Alkylation / 4: Hydrolysis / 5: Alkylation;
DOI:10.1016/S0040-4020(99)00683-3