2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

Base Information

Chemical Name:2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester
CAS No.:863578-47-6
Molecular Formula:C₂₆H₃₁NO₆
Molecular Weight:453.535
Hs Code.:

Synonyms:2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

Suppliers and Price of 2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

There total 3 articles about 2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 863578-46-5
2,4-bis(methoxymethoxy)phenylboronic acid

: 863578-47-6
2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 22h;
DOI:10.1021/jm0610245

Reference yield:

: 6626-15-9
4-Bromoresorcinol

: 863578-47-6
2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / acetone / 22 h / 20 °C

2.1: triisopropyl borate; n-BuLi / hexane; tetrahydrofuran / 5 h / -78 °C

2.2: 13.60 g / aq. HCl / tetrahydrofuran; hexane / 0.25 h

3.1: 86 percent / LiCl; Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 22 h / 90 °C

With n-butyllithium; Triisopropyl borate; sodium carbonate; potassium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; acetone; 3.1: Suzuki coupling;
DOI:10.1021/jm0610245

Reference yield:

: 295788-93-1
1-bromo-2,4-bis(methoxymethoxy)benzene

: 863578-47-6
2-(2,4-bismethoxymethoxyphenyl)-3-cyclohexyl-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triisopropyl borate; n-BuLi / hexane; tetrahydrofuran / 5 h / -78 °C

1.2: 13.60 g / aq. HCl / tetrahydrofuran; hexane / 0.25 h

2.1: 86 percent / LiCl; Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 22 h / 90 °C

With n-butyllithium; Triisopropyl borate; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; 2.1: Suzuki coupling;
DOI:10.1021/jm0610245