(4-Chlorophenyl)-1-naphthalenylmethanone

Base Information

• Chemical Name: (4-Chlorophenyl)-1-naphthalenylmethanone
• CAS No.: 1591-44-2
• Molecular Formula: C₁₇H₁₁ClO
• Molecular Weight: 266.727
• DSSTox Substance ID: DTXSID501277403
• Nikkaji Number: J3.187.695H
• Mol file: 1591-44-2.mol

Synonyms:1591-44-2;SCHEMBL8002555;DTXSID501277403;AKOS009339241;(4-Chlorophenyl)-1-naphthalenylmethanone;(4-Chloro-phenyl)-naphthalen-1-yl-methanone

Chemical Property of (4-Chlorophenyl)-1-naphthalenylmethanone

Chemical Property:

• XLogP3: 5.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 266.0498427
• Heavy Atom Count: 19
• Complexity: 319

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2C(=O)C3=CC=C(C=C3)Cl

Technology Process of (4-Chlorophenyl)-1-naphthalenylmethanone

There total 9 articles about (4-Chlorophenyl)-1-naphthalenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

carbon monoxide (201230-82-2) + 1-Iodonaphthalene (90-14-2) + tributyl(4-chlorophenyl)stannane (17151-48-3) → (4-chlorophenyl)(naphthalen-1-yl)methanone (1591-44-2)

Guidance literature:

With MCM-41-supported bidentate phosphine palladium⁽⁰⁾ complex; In N,N-dimethyl-formamide; at 80 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/b914844m

Reference yield: 74.0%

carbon monoxide (201230-82-2) + 1-Iodonaphthalene (90-14-2) + 4-Chlorophenylboronic acid (1679-18-1) → (4-chlorophenyl)(naphthalen-1-yl)methanone (1591-44-2)

Guidance literature:

With potassium carbonate; In methoxybenzene; at 80 ℃; for 5h; under 760.051 Torr;

DOI:10.1002/ejoc.200801253

Reference yield: 57.0%

1-Naphthylboronic acid (13922-41-3) + 4-chlorobenzaldehyde (104-88-1) → (4-chlorophenyl)(naphthalen-1-yl)methanone (1591-44-2)

Guidance literature:

With potassium phosphate; 3,3-dimethyl-butan-2-one; C₁₄H₁₀Cl₂N₂O₂Ru; tri tert-butylphosphoniumtetrafluoroborate; In water; toluene; at 100 ℃; for 24h;

DOI:10.1016/j.jorganchem.2013.11.019

upstream raw materials:

(4-chlorphenyl)magnesium bromide

1-Cyanonaphthalene

naphthalene

4-chloro-benzoyl chloride

Downstream raw materials:

4-chlorophenyl-1-naphthylmethanol

1-(4-chlorobenzyl)naphthalene

1-[(4-Chloro-phenyl)-naphthalen-1-yl-methyl]-1H-imidazole

4-(1-Naphthylmethyl)-benzophenon