4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Base Information

Chemical Name:4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine
CAS No.:145471-64-3
Molecular Formula:C₂₈H₂₄N₂O₅S₂
Molecular Weight:532.641
Hs Code.:

Synonyms:4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

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Chemical Property of 4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

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Technology Process of 4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

There total 8 articles about 4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 145471-63-2
4-oxo-3-(phenylsulfinyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

: 145471-64-3
4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/chem.201501912

Reference yield:

: 4942-85-2
1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-4-one

: 145471-64-3
4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) -78 deg C, 2.) -30 -> 0 deg C

2: 87 percent / 12 N NaOH / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-)

3: NaIO₄ / tetrahydrofuran; methanol; H₂O / 48 h / 20 °C

4: oxone / tetrahydrofuran; methanol / 360 h / 20 °C

With Oxone; sodium hydroxide; sodium periodate; lithium diisopropyl amide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)61005-5

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 145471-64-3
4-oxo-3-(phenylsulfonyl)-12-(p-toluenesulfonyl)-1,4,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / 12 N NaOH / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-)

2: NaIO₄ / tetrahydrofuran; methanol; H₂O / 48 h / 20 °C

3: oxone / tetrahydrofuran; methanol / 360 h / 20 °C

With Oxone; sodium hydroxide; sodium periodate; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)61005-5