1H-Benzimidazole,5-chloro-2-ethyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,5-chloro-2-ethyl-(9CI)
• CAS No.: 34569-15-8
• Molecular Formula: C9H9 Cl N2
• Molecular Weight: 180.637
• Hs Code.: 2933990090
• Mol file: 34569-15-8.mol

Synonyms:1H-Benzimidazole,5-chloro-2-ethyl- (9CI); 2-Ethyl-5-chlorobenzimidazole

Chemical Property of 1H-Benzimidazole,5-chloro-2-ethyl-(9CI)

Chemical Property:

• Melting Point: 168-170 °C
• Boiling Point: 376.0±15.0 °C(Predicted)
• PKA: 10.59±0.10(Predicted)
• PSA: 28.68000
• Density: 1.291±0.06 g/cm3(Predicted)
• LogP: 2.77870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-2-ethyl-1H-benzimidazole 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,5-chloro-2-ethyl-(9CI)

There total 1 articles about 1H-Benzimidazole,5-chloro-2-ethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propan-1-ol (71-23-8) + 4-Chloro-1,2-phenylenediamine (95-83-0) → 2-ethylbenzimidazole (1848-84-6) + 5-chloro-2-ethyl-1H-benzo[d]imidazole (34569-15-8)

Guidance literature:

With air; silver-loaded TiO₂/montmorillonite K₁₀; In acetonitrile; for 8h; Solar light irradiation;

DOI:10.1246/bcsj.20090319

Reference yield:

2,4-dinitrobenzenesulfenyl chloride (528-76-7) + 5-chloro-2-ethyl-1H-benzo[d]imidazole (34569-15-8) → N-<(2,4-dinitrophenyl)thio>-2-ethyl-6-chlorobenzimidazole + N-<(2,4-dinitrophenyl)thio>-2-ethyl-5-chlorobenzimidazole (91709-06-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 4h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00213a001

Reference yield:

5-chloro-2-ethyl-1H-benzo[d]imidazole (34569-15-8) → 5-chloro-2-ethyl-1-(4-phenoxybutyl)-1H-benzo[d]imidazole

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; sodium iodide / acetone / 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; sodium iodide; sodium hydroxide; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/acs.jmedchem.5b00546

upstream raw materials:

propan-1-ol

4-Chloro-1,2-phenylenediamine

Downstream raw materials:

N-<(2,4-dinitrophenyl)thio>-2-ethyl-5-chlorobenzimidazole

Refernces