[(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane
CAS No.:883104-65-2
Molecular Formula:C₂₆H₄₂O₃SSi
Molecular Weight:462.769
Hs Code.:

Synonyms:[(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

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Technology Process of [(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

There total 4 articles about [(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 7205-98-3
chloromethyl phenyl sulfone

: 104651-47-0
(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal

: [(1R,3aR,4S,7aR)-1-((Z)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

: 883104-65-2
[(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: chloromethyl phenyl sulfone; With n-butyllithium; diethyl chlorophosphate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 4h;
DOI:10.1021/ol060231w

Reference yield:

: 64190-52-9
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

: 883104-65-2
[(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 48 h / 60 °C

1.2: 96 percent / HCl / tetrahydrofuran / 1 h / 20 °C

2.1: 1.79 g / (diacetoxyiodo)benzene; 2,2,6,6-tetramethylpiperidinooxyl radical / CH₂Cl₂ / 5 h

3.1: n-BuLi; (EtO)2POCl / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 95 percent / hexane; tetrahydrofuran / 4 h / -78 - 20 °C

With 1H-imidazole; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; diethyl chlorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol060231w

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 883104-65-2
[(1R,3aR,4S,7aR)-1-((E)-(S)-3-Benzenesulfonyl-1-methyl-allyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 48 h / 60 °C

1.2: 96 percent / HCl / tetrahydrofuran / 1 h / 20 °C

2.1: 1.79 g / (diacetoxyiodo)benzene; 2,2,6,6-tetramethylpiperidinooxyl radical / CH₂Cl₂ / 5 h

3.1: n-BuLi; (EtO)2POCl / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 95 percent / hexane; tetrahydrofuran / 4 h / -78 - 20 °C

With 1H-imidazole; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; diethyl chlorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol060231w