biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]

Base Information

Chemical Name:biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]
CAS No.:728878-05-5
Molecular Formula:C₄₀H₄₆N₄O₇
Molecular Weight:694.828
Hs Code.:

Synonyms:biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]

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Chemical Property of biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]

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Technology Process of biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]

There total 6 articles about biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 728878-04-4
(1S,2R)-4'-(2-benzyloxy-1-benzyloxycarbamoylpropylcarbamoyl)biphenyl-4-carboxylic acid

: 75178-96-0
N-Boc-1,3-diaminopropane

: 728878-05-5
biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 728878-05-5
biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 21 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 2.5 h

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h

4: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 728878-05-5
biphenyl-4,4'-dicarboxylic acid 4'-[(3-(Boc)-aminopropyl)amide]-4-[(2R)-benzyloxy-(1S)-(benzyloxycarbamoylpropyl)amide]

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 21 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 2.5 h

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h

4: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;