N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

Base Information

Chemical Name:N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide
CAS No.:1360430-62-1
Molecular Formula:C₂₃H₂₅ClFN₅O₃
Molecular Weight:473.935
Hs Code.:

Synonyms:N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

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Chemical Property of N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

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Technology Process of N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

There total 8 articles about N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 110-91-8,99108-56-2
morpholine

: 1360430-71-2
3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

: 1360430-62-1
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

Guidance literature:: morpholine; 3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide; With potassium iodide; In ethanol; Reflux;

With potassium hydroxide; In ethanol; at 0 ℃;
DOI:10.1021/jm201507x

Reference yield:

: 53449-14-2
7-Chloro-6-nitro-quinazolin-4-one

: 1360430-62-1
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium / 72 h / Reflux

2.1: trichlorophosphate / 0.5 h / Reflux

3.1: hydrogenchloride / water; isopropyl alcohol / Reflux

4.1: iron; acetic acid / ethanol; water / 2 h / Reflux

5.1: 5 h / 50 °C

6.1: potassium iodide / ethanol / Reflux

6.2: 0 °C

With hydrogenchloride; sodium; iron; acetic acid; potassium iodide; trichlorophosphate; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm201507x

Reference yield:

: 31374-18-2
7-chloroquinazolin-4(1H)-one

: 1360430-62-1
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 1 h / 100 °C

2.1: sodium / 72 h / Reflux

3.1: trichlorophosphate / 0.5 h / Reflux

4.1: hydrogenchloride / water; isopropyl alcohol / Reflux

5.1: iron; acetic acid / ethanol; water / 2 h / Reflux

6.1: 5 h / 50 °C

7.1: potassium iodide / ethanol / Reflux

7.2: 0 °C

With hydrogenchloride; sulfuric acid; nitric acid; sodium; iron; acetic acid; potassium iodide; trichlorophosphate; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm201507x