3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

Base Information

Chemical Name:3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide
CAS No.:1360430-71-2
Molecular Formula:C₁₉H₁₇Cl₂FN₄O₂
Molecular Weight:423.274
Hs Code.:

Synonyms:3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

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Chemical Property of 3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

Chemical Property:

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Technology Process of 3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

There total 7 articles about 3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1269662-90-9
N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine

: 625-36-5
2-chloropropionyl chloride

: 1360430-71-2
3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

Guidance literature:: at 50 ℃; for 5h;
DOI:10.1021/jm201507x

Reference yield:

: 53449-14-2
7-Chloro-6-nitro-quinazolin-4-one

: 1360430-71-2
3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium / 72 h / Reflux

2: trichlorophosphate / 0.5 h / Reflux

3: hydrogenchloride / water; isopropyl alcohol / Reflux

4: iron; acetic acid / ethanol; water / 2 h / Reflux

5: 5 h / 50 °C

With hydrogenchloride; sodium; iron; acetic acid; trichlorophosphate; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm201507x

Reference yield:

: 31374-18-2
7-chloroquinazolin-4(1H)-one

: 1360430-71-2
3-chloro-N-(4-(3-Chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; nitric acid / 1 h / 100 °C

2: sodium / 72 h / Reflux

3: trichlorophosphate / 0.5 h / Reflux

4: hydrogenchloride / water; isopropyl alcohol / Reflux

5: iron; acetic acid / ethanol; water / 2 h / Reflux

6: 5 h / 50 °C

With hydrogenchloride; sulfuric acid; nitric acid; sodium; iron; acetic acid; trichlorophosphate; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm201507x