ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate)

Base Information

• Chemical Name: ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate)
• CAS No.: 1417728-97-2
• Molecular Formula: C₁₄H₁₅BrNO₂P
• Molecular Weight: 340.156
• Mol file: 1417728-97-2.mol

Synonyms:ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate)

Chemical Property of ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate)

There total 6 articles about ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-bromo-6-methylpyridin-2-yl(phenyl)phosphinic acid (1417728-96-1) + orthoformic acid triethyl ester (122-51-0) → ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate) (1417728-97-2)

Guidance literature:

at 140 ℃; for 72h; Inert atmosphere;

DOI:10.1039/c2cc35247h

Reference yield:

2-bromo-6-methyl-4-nitro-pyridine (97944-46-2) → ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate) (1417728-97-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

2.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

2.2: 0 °C

3.1: 72 h / 140 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; triethylamine; In toluene;

DOI:10.1039/c2cc35247h

Reference yield:

2-bromo-6-methylpyridine (5315-25-3) → ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate) (1417728-97-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 65 °C / Inert atmosphere

2.1: nitric acid; sulfuric acid / 16 h / 0 - 100 °C

3.1: phosphorus tribromide / chloroform / 16 h / 60 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

5.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

5.2: 0 °C

6.1: 72 h / 140 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; sulfuric acid; nitric acid; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In chloroform; toluene;

DOI:10.1039/c2cc35247h

upstream raw materials:

2-bromo-6-methylpyridine N-oxide

2-bromo-6-methylpyridine

2-bromo-6-methyl-4-nitro-pyridine-1-oxide

2-bromo-6-methyl-4-nitro-pyridine

Downstream raw materials:

ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

ethyl (4-bromo-6-methyl-1-oxo-1-pyridin-2-yl)(phenyl)phosphinate

(4-bromo-6-[ethoxy(phenyl)phosphoryl]pyridine-2-yl)methyl acetate

(6-[ethoxy(phenyl)phosphoryl]-4-[2-(4-methoxyphenyl)ethynyl]pyridine-2-yl)methyl acetate