ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

Base Information

Chemical Name:ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate
CAS No.:1421932-22-0
Molecular Formula:C₂₃H₂₂NO₃P
Molecular Weight:391.406
Hs Code.:

Synonyms:ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

Suppliers and Price of ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

There total 7 articles about ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1417728-97-2
ethyl (6-methyl-4-(bromopyridin-2-yl)(phenyl)phosphinate)

: 768-60-5
4-methoxyphenylacetylen

: 1421932-22-0
ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; at 65 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2cc35247h

Reference yield:

: 5315-25-3
2-bromo-6-methylpyridine

: 1421932-22-0
ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 65 °C / Inert atmosphere

2.1: nitric acid; sulfuric acid / 16 h / 0 - 100 °C

3.1: phosphorus tribromide / chloroform / 16 h / 60 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

5.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

5.2: 0 °C

6.1: 72 h / 140 °C / Inert atmosphere

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; sulfuric acid; nitric acid; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h

Reference yield:

: 97944-46-2
2-bromo-6-methyl-4-nitro-pyridine

: 1421932-22-0
ethyl (4-[2-(4-methoxyphenyl)ethynyl]-6-methylpyridin-2-yl)(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

2.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

2.2: 0 °C

3.1: 72 h / 140 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 3 h / 65 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1039/c2cc35247h