dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Base Information

Chemical Name:dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate
CAS No.:1372195-48-6
Molecular Formula:C₄₄H₄₇NO₉S
Molecular Weight:765.924
Hs Code.:

Synonyms:dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

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Chemical Property of dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

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Technology Process of dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

There total 6 articles about dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372195-46-4
2-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)-N,N-bis(4-methoxybenzyl)ethenesulfonamide

: 108-59-8
malonic acid dimethyl ester

: 1372195-48-6
dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Guidance literature:: malonic acid dimethyl ester; With sodium methylate; In tetrahydrofuran; methanol; for 1h;

2-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)-N,N-bis(4-methoxybenzyl)ethenesulfonamide; In tetrahydrofuran; methanol; for 17h; Reflux;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1372195-48-6
dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

1.2: 19 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 °C

2.2: -20 °C

2.3: 20 °C

3.1: sodium methylate / tetrahydrofuran; methanol / 1 h

3.2: 17 h / Reflux

With sodium methylate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1372195-48-6
dimethyl 2-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-1-(4-((2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene; tetrahydrofuran / 15 h / 20 °C / Cooling with ice

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 °C

2.2: -20 °C

2.3: 20 °C

3.1: sodium methylate / tetrahydrofuran; methanol / 1 h

3.2: 17 h / Reflux

With di-isopropyl azodicarboxylate; sodium methylate; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;