N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Base Information

Chemical Name:N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide
CAS No.:1240517-58-1
Molecular Formula:C₂₂H₂₀ClFN₄O₄S₂
Molecular Weight:523.009
Hs Code.:

Synonyms:N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

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Chemical Property of N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

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Technology Process of N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

There total 9 articles about N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1240518-46-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

: 108-24-7
acetic anhydride

: 1240517-58-1
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: With triethylamine; In chloroform; at 20 ℃;

Reference yield: 52.0%

: 1240518-47-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

: 108-24-7
acetic anhydride

: 1240517-58-1
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate; With ammonia; In methanol; water;

acetic anhydride; With triethylamine; In chloroform; at 20 ℃; for 2h;
DOI:10.1021/jm301572h

Reference yield:

: 93343-10-3
3,5-difluoroanisol

: 1240517-58-1
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: titanium chloride / dichloromethane / 0.25 h

2.1: hydroxylamine-O-sulfonic acid / water / 3 h / 110 °C

3.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h

4.2: 1 h

5.1: pyridine / chloroform / 5 h / 20 °C

6.1: lithium aluminium tetrahydride; ammonia / methanol; diethyl ether; tetrahydrofuran; water / 3 h / Inert atmosphere

7.1: methanol; dimethyl sulfoxide

8.1: ammonia / methanol; water

8.2: 2 h / 20 °C

With pyridine; lithium aluminium tetrahydride; ammonia; titanium chloride; hydrazine hydrate; potassium hydroxide; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm301572h