N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

Base Information

Chemical Name:N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate
CAS No.:1240518-47-1
Molecular Formula:CH₂O₂*C₂₀H₁₈ClFN₄O₃S₂
Molecular Weight:526.997
Hs Code.:

Synonyms:N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

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Chemical Property of N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

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Technology Process of N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

There total 8 articles about N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 64-18-6
formic acid

: 1240518-44-8
5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

: 1240518-47-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

Guidance literature:: 5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 3h; Inert atmosphere; Cooling with ice;

With sodium hydroxide; In tetrahydrofuran; diethyl ether; for 0.5h; Inert atmosphere;

formic acid; In water; acetonitrile;

Reference yield: 18.0%

: 64-18-6
formic acid

: 1240518-46-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

: 1240518-47-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

Guidance literature:: In methanol; dimethyl sulfoxide;
DOI:10.1021/jm301572h

Reference yield:

: 1240518-41-5
2,4-difluoro-6-methoxybenzonitrile

: 1240518-47-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

2.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h

2.2: 1 h

3.1: pyridine / chloroform / 5 h / 20 °C

4.1: lithium aluminium tetrahydride; ammonia / methanol; diethyl ether; tetrahydrofuran; water / 3 h / Inert atmosphere

5.1: methanol; dimethyl sulfoxide

With pyridine; lithium aluminium tetrahydride; ammonia; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; chloroform; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm301572h