C-Biphenyl-4-yl-methylamine hydrochloride

Base Information

• Chemical Name: C-Biphenyl-4-yl-methylamine hydrochloride
• CAS No.: 238428-24-5
• Molecular Formula: C₁₃H₁₃N*ClH
• Molecular Weight: 219.714
• European Community (EC) Number: 837-956-0
• ChEMBL ID: CHEMBL2403803
• DSSTox Substance ID: DTXSID50592627
• Mol file: 238428-24-5.mol

Synonyms:238428-24-5;C-Biphenyl-4-yl-methylamine hydrochloride;(4-phenylphenyl)methanamine;hydrochloride;[1,1'-Biphenyl]-4-ylmethanamine hydrochloride;EN300-6478288;c-biphenyl-4-ylmethylamine hydrochloride;c-biphenyl-4-ylmethylamine HCl;SCHEMBL1661202;CHEMBL2403803;DTXSID50592627;YISSUUJHKDXCTP-UHFFFAOYSA-N;4-aminomethyl biphenyl hydrochloride;(4-phenylphenyl)methanamine hydrochloride;DB-360193;Z2574926617;1-([1,1'-Biphenyl]-4-yl)methanamine--hydrogen chloride (1/1)

Chemical Property of C-Biphenyl-4-yl-methylamine hydrochloride

Chemical Property:

• PSA: 26.02000
• LogP: 4.31460
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 219.0814771
• Heavy Atom Count: 15
• Complexity: 153

Purity/Quality:

97% ^*data from raw suppliers

C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)CN.Cl

Technology Process of C-Biphenyl-4-yl-methylamine hydrochloride

There total 7 articles about C-Biphenyl-4-yl-methylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-cyano-1,1'-biphenyl (2920-38-9) → [1,1'-biphenyl-4-yl]methanamine monohydrochloride (238428-24-5)

Guidance literature:

4-cyano-1,1'-biphenyl; With [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]triethylphosphineruthenium(II)tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; diethylphenylsilane; at 20 ℃; for 18h; Glovebox; Inert atmosphere;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h; Glovebox; Inert atmosphere;

DOI:10.1055/s-0036-1588441

Reference yield: 92.0%

N-(4-phenyl)benzylamine (712-76-5) → [1,1'-biphenyl-4-yl]methanamine monohydrochloride (238428-24-5)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1039/c7cy01577a

Reference yield: 91.0%

biphenyl-4-carboxylic acid amide (3815-20-1) → [1,1'-biphenyl-4-yl]methanamine monohydrochloride (238428-24-5)

Guidance literature:

biphenyl-4-carboxylic acid amide; With [(aNHC)KN(SiMe₃)₂]₂; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In toluene; at 40 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;

With water; sodium hydroxide; In diethyl ether; toluene; at 40 ℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique;

With hydrogenchloride; In diethyl ether; water; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1039/c9sc05953a

upstream raw materials:

N-(4-phenyl)benzylamine

4-cyano-1,1'-biphenyl

biphenyl-4-carboxylic acid amide

Downstream raw materials:

(4-ethyl-benzyl)-methyl-(4-phenyl-benzyl)-amine

methyl-(4-methyl-benzyl)-(4-phenyl-benzyl)-amine

1-([1,1’-biphenyl]-4-yl)-N-benzyl-N-methylmethanamine