N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide

Base Information

• Chemical Name: N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide
• CAS No.: 925924-02-3
• Molecular Formula: C₂₇H₂₀ClFN₄O₅
• Molecular Weight: 534.931

Synonyms:N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide

Chemical Property of N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide

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Technology Process of N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide

There total 1 articles about N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide (925922-99-2) + chloroacetyl chloride (79-04-9) → N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide (925924-02-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 3h; Cooling with ice;

DOI:10.1016/j.bmc.2010.05.061

Reference yield: 72.0%

N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide (925924-02-3) + diethylamine (109-89-7) → N-(3-cyano-4-{3-[(N,N-diethylglycyl)amino]phenyl}-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide (925924-03-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1016/j.bmc.2010.05.061

Reference yield: 67.0%

pyrrolidine (123-75-1) + N-(4-{3-[(chloroacetyl)amino]phenyl}-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide (925924-02-3) → N-(3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-4-{3-[(pyrrolidin-1-ylacetyl)amino]phenyl}pyridin-2-yl)furan-2-carboxamide (925923-19-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1016/j.bmc.2010.05.061

upstream raw materials:

N-{4-(3-aminophenyl)-3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl}furan-2-carboxamide

chloroacetyl chloride

Downstream raw materials:

N-(3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-4-{3-[(pyrrolidin-1-ylacetyl)amino]phenyl}pyridin-2-yl)furan-2-carboxamide

N-(3-cyano-4-{3-[(N,N-diethylglycyl)amino]phenyl}-6-[4-fluoro-2-(methoxymethoxy)phenyl]pyridin-2-yl)furan-2-carboxamide

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