(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine

Base Information

Chemical Name:(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine
CAS No.:956467-58-6
Molecular Formula:C₂₁H₂₈N₂O₇S₂
Molecular Weight:484.595
Hs Code.:

Synonyms:(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine

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Chemical Property of (2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine

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Technology Process of (2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine

There total 5 articles about (2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956468-02-3
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethylpiperazine hydrochloride

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 956467-58-6
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 956467-98-4
methyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-alanyl-N-(phenylmethyl)-L-alaninate

: 956467-58-6
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: borane-THF / tetrahydrofuran / 7 h / Heating / reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: hydrogenchloride; water; hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With hydrogenchloride; borane-THF; water; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 956467-99-5
(3S,6S)-4-benzyl-3,6-dimethylpiperazine-2,5-dione

: 956467-58-6
(2S,5S)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2,5-dimethyl-4-{[4-(methyloxy)phenyl]sulfonyl}piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 7 h / Heating / reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: hydrogenchloride; water; hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C

With hydrogenchloride; borane-THF; water; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;