ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate

Base Information

Chemical Name:ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate
CAS No.:1324007-23-9
Molecular Formula:C₃₁H₂₉FN₂O₃
Molecular Weight:496.581
Hs Code.:

Synonyms:ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate

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Chemical Property of ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate

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Technology Process of ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate

There total 3 articles about ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 365547-79-1
C₁₁H₁₁FN₂O₂

: 772-38-3
4-tert-Butylphenylacetylene

: 123-11-5
4-methoxy-benzaldehyde

: 1324007-23-9
ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate

Guidance literature:: With ytterbium(III) triflate; In acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation;
DOI:10.1002/ejoc.201402633

Reference yield:

: 365547-79-1
C₁₁H₁₁FN₂O₂

: 1357256-21-3
C₂₀H₂₀O₂

: 1324007-23-9
ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; for 6h; regioselective reaction; Reflux; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.06.021

Reference yield:

: 772-38-3
4-tert-Butylphenylacetylene

: 100-07-2
4-methoxy-benzoyl chloride

: 1324007-23-9
ethyl 4-[4-(tert-butyl)phenyl]-7-fluoropyrimido-2-(4-methoxyphenyl)pyrimido[1,2-a]indole-10-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; caesium carbonate; triethylamine; In acetonitrile; 1: Sonogashira coupling;
DOI:10.1016/j.tetlet.2011.06.021