benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite

Base Information

• Chemical Name: benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite
• CAS No.: 1277151-49-1
• Molecular Formula: C₂₃H₂₄BrF₁₇NO₂P
• Molecular Weight: 780.3
• Mol file: 1277151-49-1.mol

Synonyms:benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite

Chemical Property of benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite

There total 1 articles about benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decan-1-ol (89807-86-3) + benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite (108549-21-9) → benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite (1277151-49-1)

Guidance literature:

With 1H-tetrazole; In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol2003435

Reference yield:

benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite (1277151-49-1) + 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose (4064-06-6) → C29H29BrF17O8P

Guidance literature:

With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol2003435

Reference yield:

benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl diisopropylphosphoramidite (1277151-49-1) + 2-(trimethylsilyl)ethyl 2,4-di-O-benzyl-3-O-p-methoxybenzyl-β-D-galactopyranoside (299424-48-9) → C50H53BrF17O9PSi

Guidance literature:

With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol2003435

upstream raw materials:

2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decan-1-ol

benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

Downstream raw materials:

6-(benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl phosphate)-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

6-(benzyl ammonium phosphate)-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

2-(trimethylsilyl)ethyl 2,4-di-O-benzyl-6-(benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl phosphate)-3-O-p-methoxybenzyl-β-D-galactopyranoside

2-(trimethylsilyl)ethyl 2,4-di-O-benzyl-6-(benzyl 2-bromo-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl phosphate)-β-D-galactopyranoside

Refernces