6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

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Chemical Name:6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate
CAS No.:1584148-52-6
Molecular Formula:C₂₃H₂₈N₄O₅
Molecular Weight:440.499
Hs Code.:

Synonyms:6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

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Chemical Property of 6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

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Technology Process of 6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

There total 8 articles about 6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-05-8
3-amino-3-methylbutanoic acid

: 1584148-52-6
6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: chloro-trimethyl-silane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

4: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

5: N,N-dimethyl acetamide / 1 h / 80 °C

6: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

7: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 3 h / 20 °C

8: N,N-dimethyl-formamide; isopropyl alcohol / 80 °C

With chloro-trimethyl-silane; oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 38041-19-9
4-aminotetrahydropyran

: 1584148-50-4
6-benzyl 7-methyl 5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

: 1584148-52-6
6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

Guidance literature:: In N,N-dimethyl-formamide; isopropyl alcohol; at 80 ℃;

Reference yield:

: 1584148-41-3
methyl 3-(((benzyloxy)carbonyl)(2-methoxy-2-oxoethyl)amino)-3-methylbutanoate

: 1584148-52-6
6-benzyl 7-methyl 5,5-dimethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

2: N,N-dimethyl acetamide / 1 h / 80 °C

3: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

4: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 3 h / 20 °C

5: N,N-dimethyl-formamide; isopropyl alcohol / 80 °C

With oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; isopropyl alcohol; toluene;