(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate
CAS No.:1218935-58-0
Molecular Formula:C₁₅H₁₉F₂NO₂
Molecular Weight:283.318
Hs Code.:
Mol file:1218935-58-0.mol

Synonyms:(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

Suppliers and Price of (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

There total 11 articles about (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1443623-92-4
5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

: 1218935-58-0
(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: With C₂₅H₃₀N₂O₂RuS⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); sodium formate; In water; isopropyl alcohol; at 20 ℃; for 12h;

Reference yield: 72.0%

: 399-94-0
2-bromo-1,4-difluorobenzene

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 1218935-58-0
(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; sparteine; In tert-butyl methyl ether; cyclohexane; at -78 - -70 ℃;

With zinc(II) chloride; In diethyl ether; tert-butyl methyl ether; cyclohexane; at -78 - -65 ℃;

2-bromo-1,4-difluorobenzene; With tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate; In diethyl ether; tert-butyl methyl ether; cyclohexane; at 20 ℃;

Reference yield:

: C₁₅H₂₁F₂NO₃

: 1218935-58-0
(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: With tri-tert-butyl phosphine; di-isopropyl azodicarboxylate; In tetrahydrofuran; for 20h; Reagent/catalyst; Solvent; Reflux;