Technology Process of benzyl 4-C-<2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-O-(methylthio)thiocarbonyl-D-threo-L-talo-heptit-1-yl>-2,3,6-tri-O-benzyl-4-deoxy-α-D-glucopyranoside
There total 9 articles about benzyl 4-C-<2,6-anhydro-3,4,5,7-tetra-O-benzyl-1-O-(methylthio)thiocarbonyl-D-threo-L-talo-heptit-1-yl>-2,3,6-tri-O-benzyl-4-deoxy-α-D-glucopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, r.t., 1 h, 2.) DMF, -10 deg C, 10 h
2: 1.) imidazole, NaH / 1.) THF, 60 min, 2.) THF, 60 min
3: tetrahydrofuran / 1 h
With
1H-imidazole; sodium hydride;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) LDA / 1.) THF, HMPT, -100 deg C, 30 min, 2.) THF, HMPT, 60 min
2: 87 percent / Raney nickel W II / tetrahydrofuran / 0.5 h
3: 1.) H3B*SMe2, 2.) 10percent NaOH, 35percent H2O2 / 1.) THF, 4 deg C, 3 d, 2.) THF, H2O, 30 min
4: 1.) NaH / 1.) DMF, r.t., 1 h, 2.) DMF, -10 deg C, 10 h
5: 1.) imidazole, NaH / 1.) THF, 60 min, 2.) THF, 60 min
6: tetrahydrofuran / 1 h
With
1H-imidazole; sodium hydroxide; dimethylsulfide borane complex; Raney nickel W II; dihydrogen peroxide; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) LDA / 1.) THF, HMPT, -100 deg C, 30 min, 2.) THF, HMPT, 60 min
2: 87 percent / Raney nickel W II / tetrahydrofuran / 0.5 h
3: 1.) H3B*SMe2, 2.) 10percent NaOH, 35percent H2O2 / 1.) THF, 4 deg C, 3 d, 2.) THF, H2O, 30 min
4: 1.) NaH / 1.) DMF, r.t., 1 h, 2.) DMF, -10 deg C, 10 h
5: 1.) imidazole, NaH / 1.) THF, 60 min, 2.) THF, 60 min
6: tetrahydrofuran / 1 h
With
1H-imidazole; sodium hydroxide; dimethylsulfide borane complex; Raney nickel W II; dihydrogen peroxide; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran;
