methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate

Base Information

• Chemical Name: methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate
• CAS No.: 865776-75-6
• Molecular Formula: C₁₄H₁₆N₂O₃S
• Molecular Weight: 292.359
• Mol file: 865776-75-6.mol

Synonyms:methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate

Chemical Property of methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate

There total 2 articles about methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

dichloroacetic acid methyl ester (116-54-1) + 3-Benzyloxypropanal (19790-60-4) + thiourea (17356-08-0) → methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate (865776-75-6)

Guidance literature:

dichloroacetic acid methyl ester; 3-Benzyloxypropanal; With sodium methylate; In methanol; diethyl ether; at 0 ℃; for 1.75h; Inert atmosphere;

thiourea; In methanol; for 4h; Inert atmosphere; Reflux;

DOI:10.1021/jacs.7b12692

Reference yield:

methanol (67-56-1) + 3-Benzyloxypropanal (19790-60-4) + thiourea (17356-08-0) + ethyl 1,1-dichloroacetate (535-15-9) → methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate (865776-75-6)

Guidance literature:

3-Benzyloxypropanal; ethyl 1,1-dichloroacetate; With sodium methylate; In diethyl ether;

methanol; thiourea; Heating;

DOI:10.1016/j.bmcl.2005.06.005

Reference yield: 99.0%

methyl 2-amino-5-[2-(benzyloxy)ethyl]thiazole-4-carboxylate (865776-75-6) → methyl 5-[2-(benzyloxy)ethyl]-2-bromo-1,3-thiazole-4-carboxylate (1592906-77-8)

Guidance literature:

With sulfuric acid; potassium bromide; sodium nitrite; In diethyl ether; water; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jacs.7b12692

upstream raw materials:

methanol

3-Benzyloxypropanal

thiourea

ethyl 1,1-dichloroacetate

Downstream raw materials:

5-(2-benzyloxy-ethyl)-thiazole-4-carboxylic acid methyl ester

5-(2-benzyloxy-ethyl)-thiazole-4-carboxylic acid

5-(2-benzyloxy-ethyl)-thiazole-4-carboxylic acid thiazol-2-ylamide

methyl 5-[2-(benzyloxy)ethyl]-2-bromo-1,3-thiazole-4-carboxylate