3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate

Base Information

• Chemical Name: 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate
• CAS No.: 1613057-72-9
• Molecular Formula: C₂₇H₂₉FN₂O₈
• Molecular Weight: 528.534
• Mol file: 1613057-72-9.mol

Synonyms:3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate

Chemical Property of 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate

There total 6 articles about 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4R,5R)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one (1613057-71-8) + acrylic acid (79-10-7) → 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate (1613057-72-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2014.04.062

Reference yield:

4-(2-fluoro-4-iodophenyl)morpholine (1250999-09-7) → 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate (1613057-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 - 20 °C

With dmap; copper(l) iodide; tetrabutyl ammonium fluoride; caesium carbonate; dicyclohexyl-carbodiimide; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1016/j.ejmech.2014.04.062

Reference yield:

(4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-methoxyphenyl)oxazolidin-2-one (254761-52-9) → 3-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methoxy)-3-oxopropyl acrylate (1613057-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 - 20 °C

With dmap; copper(l) iodide; tetrabutyl ammonium fluoride; caesium carbonate; dicyclohexyl-carbodiimide; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1016/j.ejmech.2014.04.062

upstream raw materials:

4-(2-fluoro-4-iodophenyl)morpholine

(4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-methoxyphenyl)oxazolidin-2-one

(4R,5R)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

acrylic acid