Sulfamic acid, dimethyl-, phenyl ester

Base Information

• Chemical Name: Sulfamic acid, dimethyl-, phenyl ester
• CAS No.: 66950-63-8
• Molecular Formula: C8H11NO3S
• Molecular Weight: 201.246
• Mol file: 66950-63-8.mol

Synonyms:

Chemical Property of Sulfamic acid, dimethyl-, phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Sulfamic acid, dimethyl-, phenyl ester

There total 5 articles about Sulfamic acid, dimethyl-, phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethylamino sulfonyl chloride (13360-57-1) + phenol (108-95-2,27073-41-2) → phenyl N,N-dimethylsulfamate (66950-63-8)

Guidance literature:

phenol; With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 0 - 23 ℃; for 0.166667h;

dimethylamino sulfonyl chloride; In 1,2-dimethoxyethane; mineral oil; at 23 ℃; for 11h;

DOI:10.1021/ja906477r

Reference yield: 75.0%

phenylchlorosulfate (16475-29-9) + trimethylamine (75-50-3) → phenyl N,N-dimethylsulfamate (66950-63-8)

Guidance literature:

In chloroform-d1; for 0.25h;

Reference yield: 70.0%

phenyl sulfamate (19792-91-7) + methyl iodide (74-88-4) → phenyl N,N-dimethylsulfamate (66950-63-8)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In benzene; at 80 ℃; for 4h;

upstream raw materials:

phenylchlorosulfate

trimethylamine

2,2,2-trifluoroethanol

phenyl betylate triflate

Downstream raw materials:

N-phenyl piperidine

4-Phenylmorpholine

1-phenyl-4-(pyridine-2-yl) piperazine

(9-ethyl-9H-carbazol-3-yl)-phenyl-amine

Refernces

• 1、 Chen, Quan,Wu, Aizhen,Qin, Shengxiang,Zeng, Meiqi,Le, Zhiping,Yan, Zhaohua,Zhang, Hua. "Ni-Catalyzed Decarboxylative Cross-Coupling of Potassium Polyfluorobenzoates with Unactivated Phenol and Phenylmethanol Derivatives". supporting information. p. 3239 - 3244. Retrieved 2018/09/10.
• 2、 Quasdorf, Kyle W.,Riener, Michelle,Petrova, Krastina V.,Garg, Neil K.. "Suzuki-Miyaura coupling of aryl carbamates, carbonates, and sulfamates". supporting information; experimental part. p. 17748 - 17749. Retrieved 2010/04/01.