ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Base Information

Chemical Name:ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate
CAS No.:538336-03-7
Molecular Formula:C₂₅H₂₈N₄O₄
Molecular Weight:448.522
Hs Code.:

Synonyms:ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Suppliers and Price of ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

There total 8 articles about ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 210962-09-7
1-(pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

: ethyl 3-[2-(2-aminoethoxy)-4-cyanophenyl]acrylate hydrochloride

: 538336-03-7
ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm020485x

Reference yield:

: 1-(4-pyridyl)-4-piperidinecarboxyic acid hydrochloride

: 132705-51-2
bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate

: 538335-99-8
ethyl 3-[2-[2-(1-tert-butoxycarbonylamino)ethoxy]-4-cyanophenyl]acrylate

: 538336-03-7
ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: With hydrogenchloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 210962-75-7
3-hydroxy-4-iodobenzonitrile

: 538336-03-7
ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / K₂CO₃; KI / dimethylformamide / 60 °C

2: 94 percent / triethylamine; Pd(OAc)2 / dimethylformamide / 100 °C

3: HCl / dioxane

4: 62 percent / triethylamine; bromotripyrrolidinophosphonium hexafluorophosphate / dimethylformamide / 20 °C

With hydrogenchloride; palladium diacetate; potassium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm020485x