4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Base Information

Chemical Name:4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt
CAS No.:1355487-27-2
Molecular Formula:C₄H₁₁N*C₁₈H₁₉ClF₂N₂O₅S
Molecular Weight:522.013
Hs Code.:

Synonyms:4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Suppliers and Price of 4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

There total 7 articles about 4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 3144-09-0
methanesulfonamide

: 1355488-77-5
4-((5-chloro-6-isobutoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoic acid

: 109-89-7
diethylamine

: 1355487-27-2
4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Guidance literature:: methanesulfonamide; 4-((5-chloro-6-isobutoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 40 ℃; Inert atmosphere;

With ammonium chloride; In water; ethyl acetate;

diethylamine; In acetonitrile;

Reference yield:

: 103877-56-1
2,5-difluoro-4-methyl-benzoyl chloride

: 1355487-27-2
4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Guidance literature:: Multi-step reaction with 5 steps

2: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

3: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 40 °C / Inert atmosphere

With N-Bromosuccinimide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1355488-71-9
methyl 2,5-difluoro-4-methylbenzoate

: 1355487-27-2
4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

2: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 40 °C / Inert atmosphere

With N-Bromosuccinimide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide;