2,5-Difluoro-4-Methylbenzoyl chloride

Base Information

Chemical Name:2,5-Difluoro-4-Methylbenzoyl chloride
CAS No.:103877-56-1
Molecular Formula:C8H5ClF2O
Molecular Weight:190.5745
Hs Code.:2916399090
DSSTox Substance ID:DTXSID40545985
Wikidata:Q72463413
Mol file:103877-56-1.mol

Synonyms:2,5-Difluoro-4-Methylbenzoyl chloride;103877-56-1;Benzoylchloride, 2,5-difluoro-4-methyl-;2,5-DIFLUORO-4-METHYL-BENZOYLCHLORIDE;SCHEMBL367845;DTXSID40545985;CFWIAKKMBXJMOJ-UHFFFAOYSA-N;MFCD04972819;2,5-Difluoro-4-methylbenzoylchloride;AKOS015912246;2,5-difluoro-4-methyl-benzoyl chloride;CS-0239444;EN300-213075

Suppliers and Price of 2,5-Difluoro-4-Methylbenzoyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,5-Difluoro-4-methylbenzoylChloride
10mg
$ 45.00

American Custom Chemicals Corporation
2,5-DIFLUORO-4-METHYLBENZOYLCHLORIDE 95.00%
1G
$ 769.65

American Custom Chemicals Corporation
2,5-DIFLUORO-4-METHYLBENZOYLCHLORIDE 95.00%
5MG
$ 500.87

Alichem
2,5-Difluoro-4-methylbenzoylchloride
1g
$ 1579.40

Alichem
2,5-Difluoro-4-methylbenzoylchloride
500mg
$ 790.55

Alichem
2,5-Difluoro-4-methylbenzoylchloride
250mg
$ 499.20

Total 10 raw suppliers

Chemical Property of 2,5-Difluoro-4-Methylbenzoyl chloride

Chemical Property:

Vapor Pressure:0.124mmHg at 25°C
Refractive Index:1.499
Boiling Point:218.7 °C at 760 mmHg
Flash Point:86 °C
PSA：17.07000
Density:1.356 g/cm³
LogP:2.65220
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:189.9996988
Heavy Atom Count:12
Complexity:186

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Difluoro-4-methylbenzoylChloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 34
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1F)C(=O)Cl)F

Technology Process of 2,5-Difluoro-4-Methylbenzoyl chloride

There total 1 articles about 2,5-Difluoro-4-Methylbenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103877-80-1
2,5-difluoro-4-methyl-benzoic acid

: 103877-56-1
2,5-difluoro-4-methyl-benzoyl chloride

Guidance literature:: With thionyl chloride;

Reference yield: 62.0%

: 67-56-1
methanol

: 103877-56-1
2,5-difluoro-4-methyl-benzoyl chloride

: 1355488-71-9
methyl 2,5-difluoro-4-methylbenzoate

Guidance literature:

Reference yield:

: 103877-56-1
2,5-difluoro-4-methyl-benzoyl chloride

: 1355487-27-2
4-{[(5-chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt

Guidance literature:: Multi-step reaction with 5 steps

2: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

3: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 40 °C / Inert atmosphere

With N-Bromosuccinimide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide;