2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

Base Information

Chemical Name:2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid
CAS No.:1024602-85-4
Molecular Formula:C₁₆H₁₈N₂O₆
Molecular Weight:334.329
Hs Code.:

Synonyms:2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

Suppliers and Price of 2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

There total 5 articles about 2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4480-83-5
1,4-dioxane-2,6-dione

: 1024869-25-7
C₁₂H₁₄N₂O₂

: 1024602-85-4
2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2012.11.104

Reference yield:

: 16642-79-8
3-(4-nitrophenyl)propionic acid

: 1024602-85-4
2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / toluene / 20 °C

2: n-butyllithium / tetrahydrofuran / -78 - 20 °C

3: hydrogen; hydrogenchloride; palladium on activated charcoal / methanol / 35 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; n-butyllithium; thionyl chloride; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2012.11.104

Reference yield:

: 107324-93-6
3-(p-nitrophenyl)propanoyl chloride

: 1024602-85-4
2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / -78 - 20 °C

2: hydrogen; hydrogenchloride; palladium on activated charcoal / methanol / 35 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; n-butyllithium; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.11.104