4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate

Base Information

Chemical Name:4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate
CAS No.:1445318-02-4
Molecular Formula:C₂₂H₂₁N₃O₈
Molecular Weight:455.424
Hs Code.:

Synonyms:4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate

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Chemical Property of 4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate

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Technology Process of 4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate

There total 6 articles about 4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1024602-85-4
2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetic acid

: 1445318-02-4
4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 18h;
DOI:10.1021/op4002998

Reference yield:

: 16642-79-8
3-(4-nitrophenyl)propionic acid

: 1445318-02-4
4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / Reflux

2.1: n-butyllithium / tetrahydrofuran / -70 °C

2.2: 0 °C

3.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / tetrahydrofuran / 1 h / 25 °C / 1277.21 Torr

4.1: tetrahydrofuran / 0.25 h / 22 °C

5.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 18 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/op4002998

Reference yield:

: 107324-93-6
3-(p-nitrophenyl)propanoyl chloride

: 1445318-02-4
4-nitrophenyl 2-(2-oxo-2-((4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenyl)amino)ethoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / -70 °C

1.2: 0 °C

2.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / tetrahydrofuran / 1 h / 25 °C / 1277.21 Torr

3.1: tetrahydrofuran / 0.25 h / 22 °C

4.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 18 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; palladium 10% on activated carbon; hydrogen; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/op4002998