3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-YL)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

Base Information

Chemical Name:3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-YL)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
CAS No.:227088-94-0
Molecular Formula:C₂₄H₂₁N₃O₅S
Molecular Weight:463.514
Hs Code.:
European Community (EC) Number:636-580-2
UNII:XY4SZP4C72
Wikidata:Q27074643
Pharos Ligand ID:HN7NZBWDP8VV
ChEMBL ID:CHEMBL338117
Mol file:227088-94-0.mol

Synonyms:2,4-Thiazolidinedione, 3-(1-(((3'-nitro(1,1'-biphenyl)-4- yl)oxy)methyl)-3-(4-pyridinyl)propyl)-;AZ 11645373;AZ-11645373;AZ11645373

Suppliers and Price of 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-YL)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AZ 11645373
5mg
$ 403.00

TRC
AZ11645373
10mg
$ 160.00

Tocris
AZ11645373 ≥98%(HPLC)
50
$ 861.00

Tocris
AZ11645373 ≥98%(HPLC)
10
$ 210.00

Sigma-Aldrich
AZ11645373 ≥98% (HPLC)
5mg
$ 141.00

Sigma-Aldrich
AZ11645373 ≥98% (HPLC)
25mg
$ 615.00

ApexBio Technology
AZ11645373
50mg
$ 1290.00

American Custom Chemicals Corporation
3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE 95.00%
5MG
$ 499.60

Total 8 raw suppliers

Chemical Property of 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-YL)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

Chemical Property:

PSA：130.62000
LogP:5.19350
Storage Temp.:2-8°C
Solubility.:DMSO: ≥10mg/mL
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:463.12019195
Heavy Atom Count:33
Complexity:688

Purity/Quality:

>98% ^*data from raw suppliers

AZ 11645373 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 37/38-41
Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1C(=O)N(C(=O)S1)C(CCC2=CC=NC=C2)COC3=CC=C(C=C3)C4=CC(=CC=C4)[N+](=O)[O-]
Uses A selective P2X7 receptor antagonist.

Technology Process of 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-YL)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

There total 4 articles about 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-YL)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2212-06-8
2-((4-bromophenoxy)methyl)oxirane

: 227088-94-0
AZ11645373

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / n-BuLi / -78 - 20 °C

2: 64 percent / Pd(Ph₃P)4; Na₂CO₃ / toluene; ethanol / 80 °C

3: Ph₃P; DEAD / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; toluene; 2: Suzuki coupling / 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2003.08.033

Reference yield:

: 227089-27-2
1-(4-Bromophenoxy)-4-(pyridin-4-yl) butan-2-ol

: 227088-94-0
AZ11645373

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / Pd(Ph₃P)4; Na₂CO₃ / toluene; ethanol / 80 °C

2: Ph₃P; DEAD / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; toluene; 1: Suzuki coupling / 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2003.08.033