4-phenoxybutanohydrazide

Base Information

• Chemical Name: 4-phenoxybutanohydrazide
• CAS No.: 111104-66-6
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.233
• Mol file: 111104-66-6.mol

Synonyms:4-phenoxy-butyric acid hydrazide

Chemical Property of 4-phenoxybutanohydrazide

Chemical Property:

• Melting Point: 79 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 417.2±28.0 °C(Predicted)
• PKA: 13.06±0.35(Predicted)
• Density: 1.125±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4-Phenoxybutanohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-phenoxybutanohydrazide

There total 2 articles about 4-phenoxybutanohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-bromovalerate (14660-52-7) + phenol (108-95-2,27073-41-2) → 4-phenoxy-butyric acid hydrazide (111104-66-6)

Guidance literature:

ethyl 5-bromovalerate; phenol; With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h;

With hydrazine; In ethanol; for 12h; Heating / reflux;

Reference yield:

γ-phenoxybutyric acid ethyl ester (2364-59-2) → 4-phenoxy-butyric acid hydrazide (111104-66-6)

Guidance literature:

With ethanol; hydrazine hydrate;

Reference yield:

4-(3-dimethylamino-pyrrolidin-1-yl)-benzoic acid (861845-97-8) + 4-phenoxy-butyric acid hydrazide (111104-66-6) → dimethyl-(1-{4-[5-(4-phenoxy-butyl)-[1,3,4]oxadiazol-2-yl]-phenyl}-pyrrolidin-3-yl)-amine

Guidance literature:

4-(3-dimethylamino-pyrrolidin-1-yl)-benzoic acid; 4-phenoxy-butyric acid hydrazide; With 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 3.16667h;

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; at 50 ℃; for 16h;

upstream raw materials:

γ-phenoxybutyric acid ethyl ester

ethyl 5-bromovalerate

phenol

Downstream raw materials:

5-(3-phenoxy-propyl)-[1,3,4]oxadiazol-2-ylamine