2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide

Base Information

Chemical Name:2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide
CAS No.:1610370-44-9
Molecular Formula:C₂₃H₂₀F₄N₂O₂
Molecular Weight:432.418
Hs Code.:

Synonyms:2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide

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Chemical Property of 2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide

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Technology Process of 2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide

There total 7 articles about 2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610370-43-8
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

: 1610370-44-9
2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; for 4.75h; under 760.051 Torr;

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 1610370-44-9
2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

3.2: 1.33 h / 90 °C

4.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; oxalyl dichloride; 5%-palladium/activated carbon; hydrogen; potassium carbonate; caesium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 24078-12-4
4-bromo-2-methylbenzaldehyde

: 1610370-44-9
2,2,2-trifluoro-N'-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)acetohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

2.2: 1.33 h / 90 °C

3.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; 5%-palladium/activated carbon; hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;