benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

Base Information

Chemical Name:benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate
CAS No.:1610370-43-8
Molecular Formula:C₃₁H₂₆F₄N₂O₄
Molecular Weight:566.552
Hs Code.:

Synonyms:benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

Suppliers and Price of benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

There total 6 articles about benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1610370-42-7
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)hydrazinecarboxylate

: 407-25-0
trifluoroacetic anhydride

: 1610370-43-8
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 1610370-43-8
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

3.2: 1.33 h / 90 °C

4.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; oxalyl dichloride; potassium carbonate; caesium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 24078-12-4
4-bromo-2-methylbenzaldehyde

: 1610370-43-8
benzyl 1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-2-(2,2,2-trifluoroacetyl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

2.2: 1.33 h / 90 °C

3.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;