3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

Base Information

Chemical Name:3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid
CAS No.:1414877-56-7
Molecular Formula:C₁₇H₁₉F₃N₂O₅
Molecular Weight:388.343
Hs Code.:

Synonyms:3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

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Chemical Property of 3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

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Technology Process of 3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

There total 2 articles about 3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1414877-58-9
3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

: 1414877-56-7
3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

Guidance literature:: 3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester; With sodium hydroxide; In ethanol; at 70 ℃; for 1.5h;

With hydrogenchloride; In water; Cooling with ice;

Reference yield:

: 1414877-57-8
di-Boc-(R)-4-(5-bromo-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1414877-56-7
3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 8 h / 70 °C / 1500.15 Torr

2.1: sodium hydroxide / ethanol / 1.5 h / 70 °C

2.2: Cooling with ice

With 1,3-bis-(diphenylphosphino)propane; triethylamine; sodium hydroxide; palladium diacetate; In ethanol; dimethyl sulfoxide;

Reference yield: 33.0%

: 1414877-56-7
3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

: 2450-71-7
Propargylamine

: 1414878-07-1
[(R)-5,5-difluoro-4-(2-fluoro-5-prop-2-ynylcarbamoyl-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester

Guidance literature:: 3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

Propargylamine; In N,N-dimethyl-formamide; for 15h;