3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

Base Information

Chemical Name:3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester
CAS No.:1414877-58-9
Molecular Formula:C₂₄H₃₁F₃N₂O₇
Molecular Weight:516.515
Hs Code.:

Synonyms:3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

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Chemical Property of 3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

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Technology Process of 3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

There total 2 articles about 3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1414877-57-8
di-Boc-(R)-4-(5-bromo-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1414877-58-9
3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

Guidance literature:: With triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In ethanol; dimethyl sulfoxide; at 70 ℃; for 8h; under 1500.15 Torr; Inert atmosphere;

Reference yield: 26.0%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 1414877-57-8
di-Boc-(R)-4-(5-bromo-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1414877-58-9
3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In dimethyl sulfoxide; at 70 ℃; for 8h; under 1500.15 Torr;

Reference yield: 85.0%

: 1414877-58-9
3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester

: 1414877-56-7
3-((R)-2-tert-butoxycarbonylamino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid

Guidance literature:: 3-((R)-2-(di-tert-butoxycarbonyl)amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-benzoic acid ethyl ester; With sodium hydroxide; In ethanol; at 70 ℃; for 1.5h;

With hydrogenchloride; In water; Cooling with ice;