(S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane

Base Information

Chemical Name:(S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane
CAS No.:145454-63-3
Molecular Formula:C₂₄H₃₆O₄Si
Molecular Weight:416.633
Hs Code.:

Synonyms:(S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane

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Chemical Property of (S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane

Chemical Property:

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Technology Process of (S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane

There total 7 articles about (S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 188400-43-3
(S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

: 100-39-0
benzyl bromide

: 145454-63-3
(S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane

Guidance literature:: (S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 25 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 25 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jacs.9b06830

Reference yield:

: 109786-74-5
(R)-3-(4-methoxybenzyloxy)propane-1,2-diol

: 145454-63-3
(S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / (1S)-10-camphorsulfonic acid / tetrahydrofuran / 2.5 h / Heating

2: 1.) Zn(BH₄)2, 2.) TMSCl, 3.) imidazole

With 1H-imidazole; chloro-trimethyl-silane; zinc(II) tetrahydroborate; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; In tetrahydrofuran;
DOI:10.1246/bcsj.65.2643

Reference yield:

: 109786-73-4
(S)-4-[(4-methoxybenzyloxy)methyl]-2,2-dimethyl-1,3-dioxolane

: 145454-63-3
(S)-(2-(benzyloxy)-3-((4-methoxybenzyl)oxy)propoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 98.7 percent / 90percent aq. acetic acid / 2.5 h / 50 °C

2: 73 percent / (1S)-10-camphorsulfonic acid / tetrahydrofuran / 2.5 h / Heating

3: 1.) Zn(BH₄)2, 2.) TMSCl, 3.) imidazole

With 1H-imidazole; chloro-trimethyl-silane; zinc(II) tetrahydroborate; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; acetic acid; In tetrahydrofuran;
DOI:10.1246/bcsj.65.2643