4-Chloro-7-fluoroquinoline

Base Information

Chemical Name:4-Chloro-7-fluoroquinoline
CAS No.:391-82-2
Molecular Formula:C9H5 Cl F N
Molecular Weight:181.597
Hs Code.:2933499090
European Community (EC) Number:826-926-2
DSSTox Substance ID:DTXSID40569121
Nikkaji Number:J1.022.132C
Wikidata:Q82456194
Mol file:391-82-2.mol

Synonyms:4-Chloro-7-fluoroquinoline;391-82-2;4-Chloro-7-fluoro-quinoline;MFCD00153094;Quinoline, 4-chloro-7-fluoro-;7-fluoro-4-chloroquinoline;SCHEMBL856135;DTXSID40569121;TTXZTTXOYYOVEV-UHFFFAOYSA-N;AKOS005259766;AB04073;4-Chloro-7-fluoroquinoline, AldrichCPR;AC-28303;DS-17067;SY025477;AM20051139;CS-0096779;EN300-76521;A924293;Z1188338617

Suppliers and Price of 4-Chloro-7-fluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-7-fluoroquinoline
100mg
$ 60.00

SynQuest Laboratories
4-Chloro-7-fluoroquinoline 97%
1 g
$ 456.00

J&W Pharmlab
4-Chloro-7-fluoro-quinoline 96%
25g
$ 840.00

J&W Pharmlab
4-Chloro-7-fluoro-quinoline 96%
1g
$ 85.00

J&W Pharmlab
4-Chloro-7-fluoro-quinoline 96%
500mg
$ 77.00

J&W Pharmlab
4-Chloro-7-fluoro-quinoline 96%
250mg
$ 68.00

J&W Pharmlab
4-Chloro-7-fluoro-quinoline 96%
5g
$ 260.00

Crysdot
4-Chloro-7-fluoroquinoline 95+%
5g
$ 255.00

Crysdot
4-Chloro-7-fluoroquinoline 95+%
10g
$ 367.00

Chemenu
4-Chloro-7-fluoroquinoline 95%
100g
$ 1468.00

Total 40 raw suppliers

Chemical Property of 4-Chloro-7-fluoroquinoline

Chemical Property:

Vapor Pressure:0.0204mmHg at 25°C
Melting Point:73.5-74 °C
Refractive Index:1.626
Boiling Point:259.9°C at 760 mmHg
PKA:2.38±0.27(Predicted)
Flash Point:111°C
PSA：12.89000
Density:1.366g/cm³
LogP:3.02730
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:181.0094550
Heavy Atom Count:12
Complexity:165

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-7-fluoroquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26-39

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(C=CN=C2C=C1F)Cl

Technology Process of 4-Chloro-7-fluoroquinoline

There total 9 articles about 4-Chloro-7-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 391-83-3
7-fluoro-4-hydroxyquinoline

: 391-82-2
4-Chloro-7-fluoroquinoline

Guidance literature:: With trichlorophosphate; at 70 ℃; for 3h;

Reference yield: 96.7%

: 391-83-3,183057-60-5
7-fluoro-1,4-dihydroquinolin-4-one

: 391-82-2
4-Chloro-7-fluoroquinoline

Guidance literature:: With trichlorophosphate; for 2h; Reflux;
DOI:10.1016/j.ejmech.2019.05.088

Reference yield:

: 372-19-0
meta-fluoroaniline

: 391-82-2
4-Chloro-7-fluoroquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 1 h / 90 - 110 °C

2: diphenyl ether / Heating

3: 2 N NaOH / Heating

4: diphenyl ether / 1 h / Heating

5: POCl₃ / 1.17 h / 100 - 110 °C

With sodium hydroxide; trichlorophosphate; In diphenylether;
DOI:10.1021/jm980146x