3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol

Base Information

Chemical Name:3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol
CAS No.:1312018-05-5
Molecular Formula:C₁₆H₁₆N₂O₄S
Molecular Weight:332.38
Hs Code.:

Synonyms:3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol

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Chemical Property of 3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol

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Technology Process of 3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol

There total 7 articles about 3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312018-04-4
5-allyl-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine

: 1312018-05-5
3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol

Guidance literature:: 5-allyl-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine; With methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine; In water; tert-butyl alcohol; at 0 ℃; for 12h;

With sodium sulfite; In water; tert-butyl alcohol; at 25 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

: 271-63-6
7-Azaindole

: 1312018-05-5
3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; formic acid / palladium 10% on activated carbon / 120 h / 0 - 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 3 h / 0 °C

3.1: bromine; pyridine / dichloromethane / 2 h / 0 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h

5.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

5.2: 12.25 h / 0 - 25 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 20 - 80 °C

7.1: 1,4-bis(9-O-dihydroquinidine)phthalazine; methanesulfonamide / water; tert-butyl alcohol / 12 h / 0 °C

7.2: 0.5 h / 25 °C

With pyridine; formic acid; methanesulfonamide; tetrabutylammomium bromide; bromine; sodium hydride; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1-(tert-butyl-dimethyl-silanyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

: 1312018-05-5
3-(1-benzenesulfonyl-pyrrolo[2,3-b]pyridine-5-yl)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine; pyridine / dichloromethane / 2 h / 0 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h

3.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

3.2: 12.25 h / 0 - 25 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 20 - 80 °C

5.1: 1,4-bis(9-O-dihydroquinidine)phthalazine; methanesulfonamide / water; tert-butyl alcohol / 12 h / 0 °C

5.2: 0.5 h / 25 °C

With pyridine; methanesulfonamide; tetrabutylammomium bromide; bromine; 1,4-bis(9-O-dihydroquinidine)phthalazine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;