5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine

Base Information

Chemical Name:5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine
CAS No.:242475-43-0
Molecular Formula:C₅₂H₆₈N₂O₉SSi
Molecular Weight:925.271
Hs Code.:

Synonyms:5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine

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Technology Process of 5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine

There total 7 articles about 5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 80971-33-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

: 242475-43-0
5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1080/07328319908044841

Reference yield: 50.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 80971-33-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

: C₅₂H₆₈N₂O₉SSi

: 242475-43-0
5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1093/nar/gkv285

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 242475-43-0
5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N; imidazole / pyridine / 12 h / 20 °C

2: 52 percent / Et₃N; DMAP / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; dmap; triethylamine; In pyridine; dichloromethane; 1: silylation / 2: Tosylation;
DOI:10.1080/07328319908044841