2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide

Base Information

Chemical Name:2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide
CAS No.:179007-53-5
Molecular Formula:C₂₁H₂₃NO₃S
Molecular Weight:369.485
Hs Code.:

Synonyms:2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide

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Chemical Property of 2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide

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Technology Process of 2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide

There total 5 articles about 2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3282-30-2
pivaloyl chloride

: 179007-51-3
3-(2-Amino-phenylsulfanylmethyl)-isochroman-1-one

: 179007-53-5
2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide

Guidance literature:: With pyridine; In dichloromethane; for 0.333333h;
DOI:10.1021/jm960093o

Reference yield:

: 610-94-6
2-bromobenzoic acid methyl ester

: 179007-53-5
2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / palladium tetrakis(triphenylphosphine) / benzene / 16 h / 100 °C

2: 98 percent / I₂ / acetonitrile / 0.5 h / 23 °C

3: 62 percent / KOH / H₂O; ethanol / 16 h / 23 °C

4: 60 percent / glacial acetic acid, zinc / 1 h / 23 °C

5: 75 percent / pyridine / CH₂Cl₂ / 0.33 h

With pyridine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; acetic acid; zinc; In ethanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1021/jm960093o

Reference yield:

: 61463-59-0
2-allyl benzoic acid methyl ester

: 179007-53-5
2,2-Dimethyl-N-[2-(1-oxo-isochroman-3-ylmethylsulfanyl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / I₂ / acetonitrile / 0.5 h / 23 °C

2: 62 percent / KOH / H₂O; ethanol / 16 h / 23 °C

3: 60 percent / glacial acetic acid, zinc / 1 h / 23 °C

4: 75 percent / pyridine / CH₂Cl₂ / 0.33 h

With pyridine; potassium hydroxide; iodine; acetic acid; zinc; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm960093o